精神分裂症神经系统软体征的多因素分析

Soft neurological signs in schizophrenia

目的：探讨精神分裂症神经系统软体征的主要影响因素。方法：对１７５例精神分裂症患者的神经系统软体征进行评定，并与年龄、病程、抗精神病药剂量、受教育年限、阴性阳性症状各因子分、ＴＥＳＳ及简明智能评定量表分进行相关分析及多元逐步回归分析。结果：多因素分析显示神经系统软体征的主要影响因素有情感谈漠、意志活动缺乏、社交活动缺乏、注意障碍、阳性思维形式障碍、病程及智能水平。

Objective: To study the associated factors of soft neurological signs in schizophrenia. Method: Soft neurological signs were evaluated in 175 patients with diagnosis of schizophrenia and correlated with age, duration of illness, dosage of antipsychotics, education level, negative and positive symptoms, TESS score and intelligence. Results:There was no association between soft neurological signs and hallucination, delusion or TESS score.Analysis with multivariant stepwise regression showed that apathy, abulia, social withdrawal, attention deficit, conceptual disorganisation, duration of illness and level of intelligence were associated with soft neurological signs. Conclusion: Soft neurological signs showed correlation with clinical parameters of the underlying pathophysiological mechanism in schizophrenia.