HBV-DNA检测与母乳喂养安全性相关研究

Serum HBV-DNA Level and Safety of Breastfeeding

目的通过比较HBs-Ag、HbeAg双阳性患者母亲采用不同喂养方式的新生儿感染状况,探讨HbeAg阳性产妇母乳喂养的安全性。方法检测HBs-Ag、HbeAg双阳性产妇血清HBV-DNA和乳汁HBV-DNA,乳汁HBV-DNA阳性产妇所产婴儿以自愿为原则分别采用母乳喂养和人工喂养。所有新生儿均在生后4～6h内注射HBIG和乙肝疫苗。结果血清HBV-DNA为103～105、106～108、>108组产妇乳汁HBV-DNA阳性率分别为19.23%、50.00%、83.33%。乳汁阳性产妇中,母乳喂养组婴儿HBs-Ag阳性率为14.29%,人工喂养组婴儿HBs-Ag阳性率为12.00%。结论产妇乳汁HBV-DNA阳性率与产妇血清HBV-DNA定量呈正相关。经联合免疫阻断母婴HBV传播后,母乳喂养与人工喂养同样安全。

Objective To investigate the relationship between the serum HBV-DNA level and the safety of breasffeeding from an HBsAg and HBeAg double-positive mother. Methods HBV-DNA in serum and breast milk of 92 pregnant women with double - positive HBsAg and HBeAg was detected. The infants born of those HBV-DNA positive mothers were fed by using breasffeeding or artificial feeding based on a voluntary principle. All the infants were injected with HBIG and hepatitis B vaccine within 4 to 6h after birth. Results The serum HBV-DNA positive rates of the lying-women breast milk with its serum HBV-DNA levels of 103- 105,106~ 10s and 〉10s were 19.23% ,50.00% and 83.33% .The HbsAg positive rates of the breasffeeding group and the artificial feeding group were 14.29% and 12.00% ,respectively. Conclusion The breast milk HBV-DNA positive rate is correlated with the serum HBV-DNA level. After receiving HBIG and hepatitis B vaccine, breasffeeding is as safe as artificial feeding to infants.