分子长效与制剂长效二氢吡啶类钙通道阻滞剂对原发性高血压患者心率及心率变异性的影响比较

The Effect of Heart Rate and Heart Rate Variability for Primary Hypertension Patients Between Molecular Long-acting and Preparation Long-acting Dihydropyridine Calcium Channel Blockers

目的探讨分子长效与制剂长效二氢吡啶类钙通道阻滞剂在降压的同时对于心率和心率变异性的影响。方法通过检索美国国立医学图书馆的医学文献检索系统及中外迄今为止发表的贝尼地平与其他长效钙通道阻滞剂比较的7篇论文,摘取其中有关贝尼地平与硝苯地平缓释制剂和氨氯地平对原发性高血压患者心率影响的内容,比较以上三种药物对心率和心率变异性的影响。结果在对心率的影响方面,分子长效药物贝尼地平明显优于制剂长效药物硝苯地平缓释制剂;与分子长效药物氨氯地平相比,有一项研究显示贝尼地平明显优于氨氯地平;在对心率变异性的影响方面,分子长效药物贝尼地平明显优于制剂长效药物硝苯地平缓释制剂,具有更高的心率变异性。结论对心率变异性的影响贝尼地平优于硝苯地平,具有更高的心率变异性,贝尼地平对原发性高血压患者心率影响优势可能与贝尼地平是L、T、N三亚型钙通道阻滞剂有关,多通道阻滞的药物可期待具有更好的心脏保护作用。

Objective To discuss the effect of heart rate and heart rate variability for primary hypertension patients between molecular long-acting and preparation long-acting dihydropyridine calcium channel blockers.Methods We choose 7 articles searched from PubMed and published articles on comparing benidipine with other long-acting calcium channel blockers,make analysis for some data on heart rate including benidipine,nifedipine and amlodipine slow-release,and compare the results on heart rate and heart rate variability.Results We found for the effect on heart rate,the result shows benidipine is better than nifedipine.A study shows benidipine obviously better than amlodipine;For the effect on heart rate variability,benidipine is better than nifedipine,and has the higher heart rate variability.Conclusion For the effect on heart rate variability,benidipine is better than nifedipine,has higher heart rate variability.The advantage of benidipine which effects on heart rate for primary hypertension patients can be related to L、T、N three sub-types calcium channel blockers,drug with multi-channel blockers can be expected to have better heart protective effect.