摘要
为了解冠心病患者血浆中６种神经肽（６ＮＰ），即神经肽Ｙ（ＮＰＹ）、降钙素基因相关肽（ＣＧＲＰ）、Ｐ物质（ＳＰ）、脑啡肽（ＥＮＫ）、神经降压肽（ＮＴ）及血管活性肠肽（ＶＩＰ）的含量，探讨其在冠心病发病中的临床意义，选择符合ＷＨＯ诊断标准的急性心肌梗死（ＡＭＩ）２０例、心绞痛（ＡＰ）３０例，应用放射免疫法动态观察血浆６ＮＰ的含量变化，并以３０例正常人作对照。结果显示：ＡＭＩ组发病第１天６ＮＰ与对照组比较，差异非常显著（Ｐ＜０．０１），第７、１４、２１天与第１天比较差异亦非常显著（Ｐ＜０．０５、Ｐ＜０．０１）；ＡＰ组于心绞痛发作期６ＮＰ的含量与对照组比较，差异亦非常显著（Ｐ＜０．０１）。经治疗２周症状缓解后复查血浆６ＮＰ含量，皆有不同程度的下降及（或）上升，前后比较有极显著性差异（Ｐ＜０．０１）。结论：血浆６ＮＰ的水平与冠心病的严重程度密切相关；
In order to study the clinical meaning of plasma levels of 6 kinds
of neuropeptide (6NP: NPY,CGRP,SP,ENK,NT and VIP) in patients with coronary heart
disease(CHD),the changes of plasma 6NP levels were observed by RIA in 20 patients with
acute myocardial infarction (AMI) and 30 patients with angina pectoris(AP) diagnosed according
to the WHO diagnosis criteria.The control group included 30 healthy persons.The results
showed that campared with normal control group,the levsls of 6NP were different significantly
on the 1st day after AMI (P<0.01).The levels of 6NP at the 7th,14th and 21th days after AMI were
also different significaltly compared with those in the 1st day after AMI(P<0.05,P<0.01).The 6NP
levels in AP group during attack were also different significartly campared with normal control
group(P<0.01).After treatment 2 weeks and symptoms relieved,the 6NP levels increased or
dicreased significantly (P<0.01).Conclusion:the 6NP might play a role in pathophysiological and
pathogenetic mechanism of ClinNeurotensinVasoactive intestinal peptide HD.The severity of
the CHD was closely correlated with the 6NP levels.
出处
《标记免疫分析与临床》
CAS
1999年第2期78-81,共4页
Labeled Immunoassays and Clinical Medicine
关键词
急性
心肌梗死
心绞痛
神经肽Y
冠心病
病理
Acute myocardial
infarctionAngina pectorisNeuropeptide YCalcitonin gene-related peptideSubstance PEnkepha
