粒系集落刺激因子在恶性淋巴瘤治疗中的作用

Effect of Granulocyte Colony-Stimulating Factor in the Treatment of Lymphoma

观察粒系集落刺激因子（G-CSF）在恶性淋巴瘤治疗中的作用。对52例恶性淋巴瘤患者随机分为二组，27例接受化疗加G－CSF治疗，25例单独应用化疗．并对60岁以上老年患者另行分组进行研究。结果显示．G－CSF治疗组在白细胞和中性粒细胞降低持续时间、患者发热持续时间、化疗总疗程后延病例数及化疗总剂量减少病例数等方面均较对照组显著减少（P＜0.05～0.001）。但临床缓解率和2年生存率两组无明显差异。对60岁以上老年患者，G－CSF治疗可显著加快白细胞和中性粒细胞数的恢复．并明显减少化疗总疗程延及总剂量减少病例数。以上结果提示．G－CSF可有效恢复化疗所致的曰细胞和中性粒细胞减少，确保化疗能足量按时完成．将对恶性淋巴瘤的治疗尤其是老年患者的治疗产生有益作用。

The effect of granulocyte colony-stimulating factor (G-CSF) in the treatment of lymphomawas investigated. Fifty two previously untreated patients with lympboma were conducted in two groups:twenty seven received chemotherapy plus G-CSF and twenty five received chemotherapy alone. Patientsaged 60 or older with non-Hodgkin's lympboma were studied particularly. The results indicated thatthe duration of the white cell count decrease, neutropenia and fever, and the numbers of patientsrequired cbemotberapy delays and total chemotherapy dose decrease were significantly reduced in theG-CSF group compared with the controls (P<0. 05). On the other hand, the addition of G-CSF did notbring significant improvement to the complete response rate and survival rate in two years. Inaddition, G-CSF, compared with control, significantly accelerated recovery of white ceel count andreduced the numbers of patients required treatment delay and total cytotoxic drug dose decrease inpatients over 60 years of age. These results suggested that G-CSF plays a important role in therecovery of cbemotberapy-induced leukopenia and ensuring most patients to receive full doses ofcbemotherapy on time. The use of G-CSF would exert beneficial effects in the treatment of patientswith lymphoma, especially in elderly patients.