自发性高血压大鼠血浆和组织胰岛素样生长因子-1含量的变化

Changes of the Content of Insulin Like Growth Factor 1 in Plasma and Tissues of Spontaneously Hypertensive Mice

为了探讨胰岛素样生长因子１在自发性高血压大鼠体内的改变与自发性高血压发生发展的病理生理过程中的关系，用放射免疫分析法测定正常和自发性高血压大鼠血浆和组织中胰岛素样生长因子－１含量。结果发现，自发性高血压大鼠心肌组织中胰岛素样生长因子－１含量显著增加（Ｐ＜０．０５），血浆中含量略有增加（Ｐ＞０．０５），而肝脏中的含量则显著降低（Ｐ＜０．０５）；两组大鼠体内均以肝脏中的胰岛素样生长因子－１含量最高。提示这些改变可能与心脏中胰岛素样生长因子－１在高血压及其心脏病变时异常增高有关。

Aim To study the effects of insulin like growth factor 1(IGF 1) on the occurence and development of hypertension. Methods The IGF 1 content in plasma and tissues of Witar kyoto rats (WKY) and spontaneously hypertensive rats (SHR) was detected by means of radioimmunoassay. Results In SHR, the content of IGF 1 was markedly increased in heart (P<0.05) and also slightly in plasma (P>0.05), but obviously decreased in liver (P<0.05). Both in WKY and in SHR the content of IGF 1 was found to be the highest in the liver. Conclusion These data suggest that the changes of IGF 1 content and distribution in SHR might associate with the pathogenesis of hypertension.