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15例非霍奇金淋巴瘤性白血病临床分析 被引量:1

Clinical Analysis in 15 Patients with Non-Hodgkin Lymphoma/Leukemia
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摘要 目的;探讨非霍奇金淋巴瘤性白血病(NHLL)的特征及治疗,提高对本病的认识。方法:回顾性分析患者住院病历资料。结果:15例患者,多数有发热、贫血、出血和肝脾淋巴结肿大等浸润表现,骨髓中均发现原始、幼稚型淋巴或淋巴样细胞,其比例达32.4%~92.8%,中位数(56.7±38.1)%,8例外周血涂片见这类细胞,8例为T、7例为B淋巴细胞系免疫表型,9例有纵隔增宽;¨例采用经典的急性淋巴细胞性白血病(ALL)治疗方案治疗,8例获得CR,但最终均因复发在20个月内死亡。结论:该病是急性白血病的一种特殊类型,本质与ALL无异;纵隔增宽、T淋巴细胞系的非霍奇金淋巴瘤(NHL)易发生NHLL;经典的ALL治疗方案有效,但长期疗效不佳。 Aim: To explore the clinical features and therapy of Non--Hodgkin Lymphoma/Leukemia (NHLL) and to improve the cognition of this disease. Methods:The clinical data of 15 patients with NHLL was analyzed retrospectively. Results:In 15 cases, most patients has clinical manifestations with fever, bleeding, infection and the symptoms of soakage with hepatosplenomegaly and lymphadeneetasis, et al. The lymphoblast were discovered in all of bone marrow(32. 4%-92.8% ,median 56.7%) and appeared in peripheral blood with 8 patients. Eight patients were T and 7 patients were B--lymphocytic NHLL. The mediastinum were broadened in 9 patients. The classical therapies with acute lymphocytic leukemia (ALL) were used in 11 patients. Among them, 8 patients were complete remission, but they died within 20 month due to the relapses. Conclusion: The disease was a special type of acute leukemia the same as ALL. The mediastinum broadened and T--lymphocytic Non--Hodgkin lymphoma (NHL) may have to evolve NHLL easily. The classical therapies with ALL were effective, but prognosis of many patients still have not better long--term curative effect.
出处 《医学信息(下旬刊)》 2010年第9期45-45,共1页 Medical information
关键词 白血病 淋巴瘤 非霍奇金 Leukemia lymphoma not hotchkin
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  • 1潘瑞彭,王鸿利.血液学及血液学检验[M].北京:人民卫生出版社,1998.214-248.
  • 2陈淑玲,汪慧英.原发性肺非霍奇金淋巴瘤1例及文献复习[J].医药前沿,2014(20):74-75.
  • 3高娜.非霍奇金淋巴瘤性白血病临床分析[J].中国社区医师(医学专业),2014,16(5):14-14. 被引量:1

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