摘要
目的；探讨非霍奇金淋巴瘤性白血病（NHLL）的特征及治疗，提高对本病的认识。方法：回顾性分析患者住院病历资料。结果：15例患者，多数有发热、贫血、出血和肝脾淋巴结肿大等浸润表现，骨髓中均发现原始、幼稚型淋巴或淋巴样细胞，其比例达32．4％～92．8％，中位数（56．7±38．1）％，8例外周血涂片见这类细胞，8例为T、7例为B淋巴细胞系免疫表型，9例有纵隔增宽；¨例采用经典的急性淋巴细胞性白血病（ALL）治疗方案治疗，8例获得CR，但最终均因复发在20个月内死亡。结论：该病是急性白血病的一种特殊类型，本质与ALL无异；纵隔增宽、T淋巴细胞系的非霍奇金淋巴瘤（NHL）易发生NHLL；经典的ALL治疗方案有效，但长期疗效不佳。
Aim： To explore the clinical features and therapy of Non--Hodgkin Lymphoma/Leukemia （NHLL） and to improve the cognition of this disease. Methods：The clinical data of 15 patients with NHLL was analyzed retrospectively. Results：In 15 cases, most patients has clinical manifestations with fever, bleeding, infection and the symptoms of soakage with hepatosplenomegaly and lymphadeneetasis, et al. The lymphoblast were discovered in all of bone marrow（32. 4%-92.8% ,median 56.7%） and appeared in peripheral blood with 8 patients. Eight patients were T and 7 patients were B--lymphocytic NHLL. The mediastinum were broadened in 9 patients. The classical therapies with acute lymphocytic leukemia （ALL） were used in 11 patients. Among them, 8 patients were complete remission, but they died within 20 month due to the relapses. Conclusion： The disease was a special type of acute leukemia the same as ALL. The mediastinum broadened and T--lymphocytic Non--Hodgkin lymphoma （NHL） may have to evolve NHLL easily. The classical therapies with ALL were effective, but prognosis of many patients still have not better long--term curative effect.
