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心肺转流期胰岛素抵抗的研究进展

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摘要 心肺转流期胰岛素抵抗受很多因素影响,包括温度、应激反应、缺血再灌注损伤、麻醉、细胞因子等。这些因素降低胰岛素敏感性,改变胰岛素受体构型,磷酸化IRS-1,抑制胰岛素受体磷酸化,激活AKT/PKB等导致胰岛素抵抗。术前口服碳水化合物,静脉输液氨基酸、胰岛素或GIK液等方法可改善胰岛素抵抗。
作者 邵栋 李立
出处 《齐齐哈尔医学院学报》 2010年第17期2779-2780,共2页 Journal of Qiqihar Medical University
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