大承气汤在严重感染治疗中的临床应用

Application of Dachengqi decoction to severe sepsis

目的 观察鼻饲大承气汤治疗严重感染的效果.方法 选择2007-05～2009-12收入我院ICU 65例严重感染伴肠鸣音消失的患者,随机分为治疗组（35例,采用常规治疗加大承气汤）和对照组（30例,采用常规治疗加安慰剂）,进行对照研究.观察两组肠鸣音恢复时间及排大便时间、全身炎症反应综合征（SIRS）消失时间及病死率等指标来判断大承气汤的治疗效果.结果 治疗组与对照组比较,肠鸣音恢复时间、排大便时间、SIRS消失时间及病死率差异具有统计学意义（P〈0.001或P〈0.05）.结论 大承气汤结合常规治疗能够改善严重感染患者的预后,降低病死率.

Objective To observe the curative effect of severe sepsis by nasal feeding Dachengqi decoction. Methods 65 cases with severe sepsis in ICU from May 2007 to December 2009 were randomly divided into treatment group （35 cases, conventional treatment and Dachengqi decoction） and control group （30 cases, conventional therapy and placebo） in order to make prospective study. Recovery time of bowel sounds, defecation time, disappearance time of systemic inflammatory response syndrome （SIRS）, mortality were observed to appraise curative effect of Dachengqi decoction. Results The recovery time of bowel sounds, defecation time, SIRS disappearance time and mortality were significantly different between two groups （ P 〈 0. 001 or P 〈 0. 05 ）. Conclusion The Dachengqi decoction combined with conventional treatment can improve the prognosis and decrease the mortality of patients with severe sepsis.