Tristetraprolin对急性肺损伤中重要炎症介质mRNA稳定性的影响及Tristetraprolin表达和功能调控的研究进展

Development of the role and regulation of Tristetraprolin in the inflammatory mediators mRNA stabilization in acute lung injury

Tristetraprolin（TTP）是一种RNA结合蛋白,能与mRNA 3′非翻译区富含AU区域结合,介导mRNA的降解.诸多研究显示,TTP对急性肺损伤中重要炎症介质的表达发挥了关键的调节作用.许多因素可以调控TTP的磷酸化状态以及亚细胞定位,其中p38 MAPK激活蛋白激酶2可以使TTP磷酸化,而蛋白磷酸酶2A可使TTP去磷酸化,通过调节TTP的磷酸化状态以及亚细胞定位影响其降解mRNA的功能和相应炎症介质的表达.

Tristetraprolin（TTP） is an RNA -binding protein that binds to an AU -rich element in the 3＇- untranslated region of its target mRNAs and accelerates the degradation of mRNAs. Many studies showed that TTP played a critical role in the regulation of inflammatory mediators expression in acute lung injury. A series of factors could regulate the phosphorylation state and subcellular localisation of TTP,of whom p38 MAPK activated protein kinase- 2 phosphorylates TFP, while Protein Phosphatase 2A dephosphorylates TTP, then they influenced the function of TTP- mediated mRNA decay and the inflammatory mediators expression.