东川芎乙醇提取物对小鼠学习记忆的影响

Effect of Cnidium offcinale Makino ethanol extract on the memory in mice

目的:观察东川芎乙醇提取物对小鼠学习记忆的改善作用。方法:腹腔注射氢溴酸东莨菪碱注射液(SCOP)制备小鼠记忆障碍模型,采用避暗实验、跳台实验、水迷宫实验和Y型电迷宫穿梭实验等方法观察不同剂量东川芎乙醇提取物对记忆障碍模型小鼠的作用效果。结果:与模型组比较,东川芎乙醇提取物中、高浓度组均能改善记忆障碍,作用强度类似于石杉碱甲。结论:东川芎乙醇提取物对SCOP诱导的小鼠记忆障碍具有良好的改善作用。

OBJECHVE To observe the effect of Cnidiurn offcinale Makino ethanol extract （COM） on the memory in mice. METHODS The memory dysfunction was induced by ip administration of scopolamine hydrobromide （SCOP）, and the memory abilities were measured through the step-through test, the step-down test, the water maze test and the Y-electric maze test. In the each test, 48 mice were randomly divided into control group, model group, huperzine A treated group, COM-high dose treated group（COM group A）, COM-middle dose treated group （COM group B） and COM-low dose treated group （COM group C）. RESULTS The studies showed that COM high and middle dose treated groups improved memory dysfunction compared with model group （P〈0. 05） significantly, and the efficacy was similar to huperzine A treated group. But COM-low dose treated group had no memory improving effect. CONCLUSION The suitable dosages of Cnidium offcinale Makino alcohol extract could improve memory dysfunction in mice.