稳态时健康人体内甲磺酸帕珠沙星对多索茶碱药动学的影响

Effect of pazufloxacin mesilate on pharmacokinetics of doxofylline at steady state in healthy volunteers

目的:探讨稳态时甲磺酸帕珠沙星对健康人体内多索茶碱药动学的影响。方法:采用自身交叉试验设计,8名受试者随机分为2组,单用组多索茶碱给药4d;合用组甲磺酸帕珠沙星和多索茶碱联合用药4d。1周后交换给药。采用HPLC法平行监测合用药前后多索茶碱的血药浓度。结果:两药合用时,多索茶碱的t1/2β明显延长、AUC明显增加、CL/F明显下降。结论:甲磺酸帕珠沙星能抑制多索茶碱在健康人体内的消除,提示两药长期合用时应对多索茶碱进行血药浓度监测。

OBJECTIVE To study the effect of pazufloxacin mesilate on pharmacokinetics of doxofylline at steady state in healthy volunteers. METHODS A randomized, crossover and self-control study with a wash period of 1 week was conducted and 8 healthy volunteers were divided into doxofylline（I） and pazufloxaein mesilate/doxofylline （II） groups and orally taken doxofylline and pazufloxacin mesilate/doxofylline for 4 days. The blood serum was collected and doxofylline and pazufloxacin concentrations were measured by HPLC. RESULTS Compared to group I, AUC, t1/2β, CL/F are significantly different between groups （P〈0. 05）. CONCLUSION Pazufloxacin mesilate may decrease the elimination of doxofylline in healthy volunteers. Doxofylline monitoring is needed when coadmistered with pazufloxacin mesilate for a long period.