慢性肾脏病脂质异常的治疗及意义

Statins for dyslipidemia in chronic kidney disease

血脂异常是慢性肾脏病患者的常见表现,它与慢性肾脏病的进展互为因果,共同参与慢性肾脏病高发心血管并发症和病死率。治疗中除了生活方式改变,强调他汀类药物治疗在慢性肾脏病患者血脂异常的早期治疗,副反应较一般人群无明显增加。已经看到他汀类药物治疗能够降低慢性肾脏病患者高发心血管事件和全因病死率,对降低尿蛋白和延缓肾脏病进展的益处还需要更多证据来证实。

Dyslipidemia is a common complication of chronic kidney disease（CKD）. It worsens with the progression of CKD, and plays an important role in high morbidity and mortality of accelerated cardiovascular（CVD） events. In addition to therapeutic lifestyle changes, this review emphasizes statins therapy in early stages of CKD patients, to decrease the CVD events and all-cause mortality. The effects of statin on alleviate proteinuria and progression of CKD are investigated in ongoing RCTs.