期刊文献+

临床轻症IgA肾病尿蛋白质组学研究 被引量:2

Study of urinary proteomes in patients with mild IgA nephropathy
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摘要 目前IgA肾病(IgAN)的诊断主要依赖肾活检病理检查,临床无创性检查判断IgAN进展的可靠指标很少,所以迫切需要一种可靠、无创的手段来诊断IgAN,减少重复肾活检次数,并预测疾病进展。近年来,蛋白质组学被广泛应用于人类疾病病理生理机制、治疗和药物筛选的研究,它可以同时检测标本中的所有表达蛋白,
出处 《中国实用内科杂志》 CAS CSCD 北大核心 2010年第10期930-932,共3页 Chinese Journal of Practical Internal Medicine
关键词 IGA肾病 尿蛋白质组 二维凝胶电泳 质谱 IgA nephropathy urinary proteome two-dimensional gel electrophoresis mass spectrometer
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同被引文献40

  • 1李雪竹,严海东.尿β_2微球蛋白、NAG测定对肾功能评价的意义及其与年龄的关系[J].中国医科大学学报,2006,35(3):314-315. 被引量:18
  • 2彭艾,顾勇,肖涛,朱开元,张明,杨海春,林善锬.伴足细胞尿的IgA肾病的临床病理特征[J].中华肾脏病杂志,2007,23(5):283-287. 被引量:15
  • 3Wild S, Roglic G,Green A, et al. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care, 2004,27:1047-1053.
  • 4DAmico G. Natural history of idiopathic IgA nephropathy: role of clinical and histological prognostic factors. Am J Kidney Dis, 2000,36 : 227-237.
  • 5Hogg RJ, Wyatt RJ. A randomized controlled trial of myco- phenolate mofetil in patients with IgA nephropathy [ISRCTN62574616]. BMC Nephrol, 2004,5 : 3.
  • 6Pisitkun T. Discovery of urinary biomarkers. Mol Cell Pro- teomics, 2006.5 : 1760-1771.
  • 7Rovin BH, Tan LC. LDL stimulates mesangial fibroneetin pro- duction and chemoattraetant expression. Kidney Int, 2005,43 : 218-225.
  • 8Tortes DD, Rossini M, Manno C, et al. The ratio of epidermal growth factor to monocyte chemotactic peptide-1 in the urine predicts renal prognosis in IgA nephropathy. Kidney Int, 2008, 73 : 327-333.
  • 9Tomomi A, Tadaatsu I, Kazushi T, et al. Urinary fractalkine and monoeyte chemoattractant protein-l,as possible predictors of disease activity of childhood glomerulone nephritis. Tohoku J Exp Meal,2013,265-270.
  • 10Stangou M, Papagianni A, Bantis C, et al. Up-regulation of uri- ary markers predict outcome in IgA nephropathy but their pre- dictive value is influenced by treatment with steroids and aza- thioprine. Chin, Nephrol, 2013,80 : 203-210.

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