从HBV持续性感染的免疫学机制探讨乙型肝炎相关性肾炎的免疫治疗

The immunological mechanism HBV persistent infection and the immune therapy of hepatitis B virus associated glomerulonephritis

患者感染乙型肝炎病毒(HBV)后受病毒本身特性及其免疫状态的影响,可出现几种不同的结局。其中,宿主免疫功能低下或病毒变异逃避免疫攻击而导致HBV持续性感染是目前最棘手的问题。HBV持续感染使肝外并发症之一的乙肝相关性肾炎发生风险大大增加,当病毒在肾组织细胞内持续复制,可诱导细胞凋亡、增殖等病理损伤。本文对此作为综述。

Different immunity state could create different prognosis of hepatitis B virus. Glomerulonephritis is an uncommon complication of chronic hepatitis B virus （HBV） infection. HBV persistent infection,which induced pathologic damage （such as cell apoptosis and proliferation ） and HBV replication in renal tissue, had increased the incidence of hepatitis B virus associated glomerulonephritis （HBV-GN）. Host＇s immunodeficiency and virus＇ variation were thought to be the most delicate contribution to HBV persistent infection. We aimed to summarize the immunological mechanism of HBV persistent infection and the immune therapy of HBV-GN,which maybe provide a new therapy of HBV-GN.