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系统性红斑狼疮患者外周血单核细胞CD40表达及临床意义 被引量：1

The Expression of CD40 on Monocytes from SLE Patients and Their Clinical Significance
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摘要 目的 对SLE患者外周血单核细胞上CD40的表达水平及其与SLEDAI评分有无相关性进行分析.方法 用免疫荧光标记和流式细胞仪技术检测21例SLE患者和18名正常人外周血单核细胞上CD40的表达.结果 SLE患者外周血中CD14＋CD40＋/CD14＋百分率明显高于正常对照组（P〈0.01）.SLE患者外周血CD14＋细胞CD40表达水平和SLEDAI评分呈正相关.结论 SLE患者CD14＋CD40＋/CD14＋高于正常人,认为单核细胞CD40表达增高参与SLE的发病过程. Objective To analyze whether the expression of CD40 on monocytes of SLE patients is abnormal. Methods The expression of CD40 on monocytes in SLE patients and normal controls was examined by immunofluorescence and flow cytometry. Result The percentage of CDI4＋CD40＋ among CD14＋ cells from patients with SLE is higher than that of normal controls.There is positive relationship between the expression of CD40 on monocytes from SLE patients and SLEDA1 scores.Conclusion The elevated expression of CD40 on monocytes of SLE patients may take part in the pathogenesis of SLE.
作者 黎曼 柴华旗
机构地区 苏州市市立医院北区肾内科 苏州大学附属第一医院肾内科
出处 《中国血液流变学杂志》 CAS 2010年第3期392-394,共3页 Chinese Journal of Hemorheology
关键词 系统性红斑狼疮 单核细胞 CD40 Systemic lupus erythematosus Monocyte CD40
分类号 R446.11 [医药卫生—诊断学] R544.1 [医药卫生—心血管疾病]
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参考文献10

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  • 6Ellen H S, Sander B N, Nic R B, et al. Stress and innate immu- nity in carp:eorticosteroid receptors and pro-inflammatory cyto- kines[J]. Molec. hnmunol.,2008,46:70-79.
  • 7Genciana T, Rosalba G,Simon A R.Quantification of a glucoeorti- coid receptor in sea bass(Dicentrarchuslabrax,L) reared at high stocking density[J].Gene, 2005,357(2):144-151.
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  • 9Gadan K, Marjara I S, Sundh H, et al. Slow release cortisol im- plants result in impaired innate immune responses and higher in- fection prevalence following experimental challenge with infec- tious pancreatic necrosis virus in Atlantic salmon (Salmo salar) parr[J].Fish Shellfish Immunol., 2012,32:637-44.
  • 10Hideya T, Tatsuya S.The role of 'mineralocorticoids' in teleost fish: Relative importance of glucocortieoid signaling in the osmo- regulation and 'central' actions of miueralocorticoid receptor[J]. Gen. Comp. Endocri., 2013,181:223-228.

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中国血液流变学杂志
2010年 第3期

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