以莫西沙星为基础的三联疗法根除幽门螺旋杆菌(附63例)

Effect of Moxifloxacin-based Triple Therapies for H.pyloai Eradication (63 Case)

目的:观察以莫西沙星为基础的三联疗法根除幽门螺旋杆菌感染临床疗效和耐受性。方法:选取幽门螺旋杆菌感染患者63例,随机分两组,接受7d的抗幽门螺旋杆菌治疗。莫西沙星组予以莫西沙星400mg/次,1次/d;阿莫西林1g/次,2次/d;奥美拉唑20mg/次,2次/d。对照组予以克拉霉素500mg/次,2次/d;阿莫西林1g/次,2次/d;奥美拉唑20mg/次,2次/d。停药4周后行13C呼气试验检测幽门螺旋杆菌,对比两组幽门螺旋杆菌根除率,并评价耐受性。结果:莫西沙星组幽门螺旋杆菌根除率为90.3%,对照组为78.1%,具有显著性差异(P<0.05)。结论:莫西沙星对幽门螺旋杆菌的根除率明显优于克拉霉素。

Objective： To observe the clinical effect of moxifloxacin-based therapies for H. pylori eradication. Methods： In this random control study,63 H. pylori-positive patients were divided into moxifloxacin （moxifloxacin 0. 4 g,qd,amoxicillin 1. 0 g,bid,omeprazole 20 mg,bid） group and control （clarithromycin 0. 5 g,qd,amoxicillin 1. 0 g,bid,omeprazole 20 mg,bid） group. The patients in both groups were treated for 7 days. H. pylori status were assessed 4 weeks after the end of treatment by 13 C urea breath test. Results： The rates of H. pylori eradication in moxifloxacin group and control group were 90. 3% and 78. 1% ,respectively,and there was statistical difference between them （P〈0. 05） . Conclusions： The rate of H. pylori eradication in moxifloxacin is better than that in clarithromycin.