我院420例药品不良反应报告分析

Analysis of 420 ADR Cases in our Hospital

目的:分析我院药品不良反应(ADR)发生的特点和规律,以期为临床合理用药及未来的ADR监测工作提供参考。方法:对我院2006年～2009年收集到的420例ADR报告分别从患者年龄及性别、发生时间、给药途径、涉及药品、涉及器官(系统)及临床表现等方面进行统计分析。结果:420例ADR报告中共涉及13大类药品,117个品种。ADR构成比最高的为抗微生物药(48.97%),静脉给药方式是导致ADR的主要因素(75.48%),ADR临床表现以皮肤及其附件损害最为常见(42.05%)。结论:医院必须重视ADR的监测和报告工作,加强临床与药师之间的沟通,合理规范使用药物,减少或避免ADR的发生。

Objective： To analyze the characteristics and regularity of adverse drug reactions（ADR） in our hospital in order to provide information for rational drug use in clinical practice and ways of clinical ADR monitoring in the future. nethod：A total of 420 ADR cases collected in our hospital during the period of 2006 -2009 were statistically analyzed in respect of distribution of age and gender, routes of drug administration, organs or systems and clinical manifestations, etc. Result：A total of 117 kinds of drugs belonging to 13 major categories of drugs were involved in 420 ADR events, antibiotics drugs dominated the first place（48.97% ）, and 75.48% of ADRs were induced by intravenous means. The major systems involved in were skin and its appendages （42.05%）. Conclusion ：It is important to intensify ADR monitoring and facilitate communications between pharmacists and clinicians in order to reduce or avoid ADR events.