直肠半结扎模型大鼠的病理改变

Pathological changes in rat model of rectal semi-ligation

目的探讨"肺合大肠"中医脏腑相关理论实验基础。方法复制大鼠直肠半结扎模型,观察心、肝、肾、肺和肠等器官的形态学改变,观察肺泡灌洗液细胞分类计数变化以及大承气汤的干预效果。结果解扎组大鼠直肠黏膜层变薄,平滑肌萎缩;肺脏表现有间质性炎症,局部可见肺泡扩张,肺出血,肺泡壁破裂,肺气肿样改变,周边肺泡塌陷、不张;其他脏器未见明显病变;肺泡灌洗液中淋巴细胞数量增多。大承气汤治疗后上述变化明显减轻。持续结扎组病变较解扎组更为明显。结论肠道病变可引起特异性的肺脏损害;治疗肠道病变,肺脏损害亦随之减轻,从一个侧面印证了中医"肺合大肠"脏腑相关理论,肺-肠病理生理存在一定的相关性及互动调节现象。

Objective To investigate the experimental base of relevant TCM zang-fu theory-lung associated with large intestine.Methods The rat model of rectal semi-ligation was established.The morphological changes were observed in the heart,liver,kidney,lung and intestines.The changes of differential cell count in alveolar lavage fluid and the interventional effect of Dachengqi Decoction were studied.ResultsIn the ligation group,the rectal mucosa became thinner,and atrophy of smooth muscle was observed.The pathological changes in the lung included interstitial inflammation,local alveolar ectasia,pneumorrhagia,alveolar septum rupture,emphysema-like change,and peripheral alveoli atelectasis.Other organs did not manifest obvious pathological changes.The count of lymphocytes increased in alveolar lavage fluid.The pathological changes was more significant in the ligation group than that in the removal group.The above changes were alleviated after the treatment with Dachengqi Decoction.Conclusion The pathological changes in large intestine can arouse specific lung lesion,and the treatment of intestine disease can alleviate lung lesion,which proves the relevant TCM zang-fu theory about viscera and lung associated with large intestine.There is correlation and interactive regulation between lung and large intestine in pathology and physiology.