颈动脉粥样硬化斑块与血脂和血栓素相关性研究

RELATIONSHIP BETWEEN CAROTID ATHEROSCLEROTIC PLAQUE,BLOOD LIPID AND THROMBOXANE

目的研究颈动脉粥样硬化斑块与血脂和血栓素B_2和6-酮-前列腺素F_1α的关系。方法 70例受试者经颈动脉超声检查,分为斑块组、对照组。抽取受试者清晨空腹肘静脉血,检测血糖、血脂及血栓素B_2、6-酮-前列腺素F_1α。结果 2组受试者血脂水平比较,斑块组患者的总胆固醇水平明显高于对照组,差异有统计学意义(P<0.05),斑块组与对照组相比,血糖、血栓素指标明显异常。斑块组中总胆固醇和三酰甘油与血栓素B_2呈正相关(r=0.344 9,r=0.355 3,P均<0.05),低密度脂蛋白胆固醇与6-酮-前列腺素F_1α呈正相关(r=0.317 5,P<0.05)。结论胆固醇增高和血栓素异常可能对颈动脉粥样硬化斑块的形成起促进作用。

Objective To investigate the relationship between atherosclerotic plaque in carotid artery, blood lipid and thromboxane. Methods Seventy patients with carotid atherosclerosis were examined by uhrasonography and were divided into plaque group （n = 50） and nonplaque group （n = 20 ）. Thromboxane B2 （ TXB2 ）, 6 - keto - prostacyclin - 1 alpha （6 - Keto - PGF1 o~）, blood sugar, blood lipid of the two groups were observed. Results The levels of cholesterol, blood sugar, TXB2, 6 - Keto - PGF1α, and TXB2/6 -Keto -PGF1 α were significantly higher in plaque group than those in nonplaque group. In the plaque group, cholesterol and triglyeerides were positively correlated with TXB2, and low density lipoprotein cholesterol was positively correlated with 6 - Keto - PGF1α. Conclusion Hypereholesterolemia and abnormal thromboxane may contribute to the atheroselerotic plaque in carotid artery.