摘要
目的探讨不同类型慢性乙型肝炎患者病毒复制水平与肝损害程度的关系。方法 150例慢性乙型肝炎(轻度70例、中度60例、重度20例)患者血清HBV DNA含量采用荧光标记(Ampli Sensor)定量PCR方法检测。结果慢性乙型肝炎轻度、中度患者HBV DNA含量(105.58±1.92、106.27±2.05)与慢性乙型肝炎重度患者HBV DNA含量(105.73±1.90)相比较无显著性差异(P>0.05),且不同HBV DNA水平患者的TBil、ALT、AST差别无显著性(P>0.05)。结论随着肝损害程度的加重,慢性乙型肝炎轻度、中度、重度患者血清HBV DNA基因含量未发生显著变化,同时血清HBV DNA含量与TBil、ALT、AST水平无明显关系。
Objective To explore the relationship between the nucleic acid content of hepatitis B virus and liver function and its pathological state of patients with different clinical types of chronic hepatitis B.Methods Fluorescence quantitative PCR was used to measure the HBV DNA was used to detect the hepatitis B virus markers in 150 cases.Results There were not significant difference between HBV DNA content and different clinical types of chronic hepatitis B（P0.05）.Conclusion There is not significant correlation between liver inflammation stage and serum HBV DNA content in different clinical types of chronic of hepatitis B.
出处
《中国医药指南》
2010年第29期199-200,共2页
Guide of China Medicine
