血清一氧化氮在病毒性肝炎中的临床意义

Detection of Serum Nitric Oxide and Endotoxin in Patients with Viral Hepatitis and Significances

目的:探讨NO在病毒性肝炎中的作用及机制。方法:用分光光度比色分析法检测83例病毒性肝炎患者血清NO和内毒素水平。结果:各病毒性肝炎组NO和内毒素水平均高于正常对照组(P<0.01),重型肝炎组NO水平低于急性和慢性组(P<0.01),而内毒素水平高于急性和慢性组(P<0.01)。结论:病毒性肝炎患者NO水平明显升高,且可能对肝脏有保护作用,

Aim: To determine the role of nitric oxide (NO) in the patients with viral hepatitis. Methods: The serum NO and endotoxin levels were measured by spectrophotometry. Results: The serum NO and endotoxin of patients with viral hepatitis were significantly higher than that of nomal controls (P<0. 01). The serum NO levels of patients with hepatitis grave were significantly lower than that of patients with acute hepatitis and chronic hepatitis (P<0. 01). But the serum endotoxin levels were significantly higher than that of patients with acute hepatitis and chronic hepatitis (P< 0. 01 ). Conclusion: The serum NO levels of viral hepatitis were significantly high and NO plays a protective role in livers.