热籽磁感应加温在肌肉体模中的升温效果

Effects of Thermal Seed Magnetic Induction Heating in Muscle Phantoms

为了探讨不同数量和不同排布方式下,热籽在等效肌肉的琼脂体模中磁感应升温效果,制作琼脂等效肌肉模型,利用模板植入不同数量热籽:1颗、2颗、3×3阵列排布、4×4阵列排布、双层4×4不同层间距排布。在选择的测温点植入热电偶,将植入完成的琼脂体模置于磁极下,进行磁场辐照,测定并记录升温情况。结果表明,1颗和2颗热籽植入体模在磁场中加热后温度可达25～32℃,热籽在体模中的发热功能稳定。9颗热籽植入体模在磁场中加热后,两颗热籽间温度达到37.5℃,热籽阵外1.0cm处温度为30.1℃。16颗热籽植入体模在磁场中加热后,热籽阵列中心温度达到52.9℃。不同层间距热籽植入体模在磁场中加热后,中心点位置温度均达到65℃以上。随着逐渐远离中心点,温度呈下降趋势,在热籽阵外1.0cm处降至42～45℃。层间距1.0cm与0.8cm的结果比较,各测温点间温度相差约1.0℃;层间距1.0cm与层间距0.5cm的结果比较,各测温点间温度相差约3.0℃。因此,本研究成功模拟了等效肌肉的琼脂体模,一定数量的热籽在既定靶区磁感应升温,可以达到肿瘤治疗所需温度。

We explored the effects of different amounts and different arrangements of thermal seeds with magnetic induction heating in an experimental muscle model（agar phantom）.The agar phantoms were generated using thermal seed implant templates with the following features：single stars;2 stars;3×3 array of exclusive fabrics;4×4 array row cloth;double layers 4×4 different spacing row cloth.A thermocouple was implanted to measure the temperature of the agar phantom.The agar phantom was then placed on poles to provide a magnetic field to heat the thermal seeds.In models containing one or two thermal seeds,the temperature reached 25～32℃ upon heating.This heating function of the thermal seeds was also stable.In another model containing nine thermal seeds,the temperature reached 37.5℃ between two thermal seeds,while the temperature 1.0cm away from the thermal seed array was 30.1℃.In a model containing 16 thermal seeds,the center of the thermal seed array center reached 52.9℃ after applying the magnetic field.In tests of different spatial distances of the thermal seed in the magnetic field,the temperature at the center reached ≥65℃,and progressively decreased with increasing distance from the focal point,dropping to 42～45℃ at 1.0cm away from the thermal seed array.Comparing models with a layer spacing of 1.0cm and 0.8cm,the difference in temperature was approximately,1.0℃.In comparisons of tests with layer spacing of 1.0cm and 0.5cm spacing,the temperature difference between the measured points was about 3.0℃.Here,we have shown that,in an experimental model of muscle（agar phantom）,magnetic induction of thermal seeds within a specific target area can provide a temperature suitable for cancer thermal ablation.