缺氧缺血性脑病患儿血清IL-6、TNF—α和NPY水平检测的临床意义

Cfinical significance of changes of serum IL-6 TNF-α and NPY levels in patients with Hypoxic Ischemic Encephalopathy（HIE）

目的探讨缺氧缺血性脑病患儿血清IL-6、TNF—α和NPY水平检测的临床意义。方法应用放射免疫分析法对32例缺氧缺血性脑病患儿进行了血清IL-6、TNF-α和NPY水平测定，并与35名健康人作比较。结果缺氧缺血性脑病患儿血清IL-6、TNF—α和NPY水平非常显著地高于正常人组（P〈0．01），且血清IL-6、TNF-α和NPY水平呈正相关（r=0．6045、0．5714．P〈0．01）。结论检测血清IL-6、TNF-α和NPY水平的变化对了解病情、观察预后均具有十分重要的临床价值。

Objective To explore the clinical significance of changes of serum IL-6 TNF-α and NPY levels in patients with HIE. Methods Serum IL-6 TNF-αand NPY levels （ with RIA） were detected in 32 patients with HIE, as well as 35 controls. Results Serum IL-6 TNF-αand NPY levels were significantly higher in the patients HIE than those in controls（ P 〈 0.01 ）. Serum IL-6 levels were positively correlated to serum TNF-α and NPY levels （ r = 0. 6045,0. 5714, P 〈 0. 01 ）. Conclusion Serum IL-6 TNF-α and NPY levels are closely related to the diseases process of HIE and determination of which are of great clinical importance.