特发性生长激素缺乏症少儿垂体磁共振成像研究

MRI study of pituitary gland morphology in idiopathic growth hormone deficiency in stage of adolescent

目的研究特发性生长激素缺乏症(IGHD)少儿垂体磁共振成像(MRI)表现。方法选取北京协和医院内分泌科2005年1月至2010年1月确诊的100例IGHD患儿,均行MRI平扫及增强检查,与152例同年龄同性别健康少儿(正常组)匹配分析比较。结果 IGHD少儿鞍区MRI主要表现为垂体发育不良、垂体后叶异位或缺如、垂体柄变细中断甚至消失。IGHD组与正常组垂体上缘形态及信号特点差异具有统计学意义。IGHD组垂体高度和垂体柄宽度明显低于正常组(P<0.01)。结论 IGHD少儿垂体形态有特征性改变,根据临床与实验室检查再结合垂体MRI表现对诊断IGHD具有明显帮助。

Objective To study the changes of shape, size and signal intensity of pituitary gland in idiopathic growth hormone deficiency（IGHD）in adolescent. Methods Clinical data of pituitary MRI of 100 puberty with IGHD were cho- sen from the Endocrine Department of Peking Union Medical College Hospital fi＇om January 2005 to January 2010. Compared these results with the normal. Results There were significant difference of the superior shape of the pituitary and the MR1 signal between the study group and control group. The height of pituitary gland and the width of pituitary stalk in the study group were significantly smaller than the control group （P 〈 0.01 ）. There were three major imaging features of the pituitary MRI in IGHD cases： the pituitary hypoplasia, the posterior lobe of pituitary dystopia or disappear and the pituitary stalk thinning or disappear. Conclusion There is a remarkable change of the pituitary in IGHD cases.h is nec- essary to combine the MRI of the pituitary with the clinical and laboratory findings to diagnose IGHD.