中华胃康对实验性胃溃疡及HP抑制作用的研究

Studies on Anti-gastric Ulcer Action of Zhonghuaweikang in Rats Mice and Inhibitory Effect on Helicobacter Pylori

应用大、小鼠胃溃疡实验性胃溃疡模型，研究中华胃康的抗溃疡作用。结果证明，中华胃康5～20mg·kg－1，明显抑制大鼠应激性、幽门结扎型、利血平型、消炎痛型和小鼠组织胺型胃溃疡，并伴有胃液量、胃酸、胃蛋白酶活性降低，Alcian－blue测胃粘液合成增加；并可促进乙酸型溃疡愈合；效应与剂量相关。对幽门螺旋菌（HP）具有强烈抑制作用，MIC为0．024～0．048mg·kg－1。

The purpose of this paper is to use a gastric ulcers model to study the effects of Zhonghua Weikang (ZHWK)in rats、 mice. The results showed that ZHWK 5～20mg. kg-1 inhibited the rat gastric ulcers induced by stress, pyloric ligation,reserpine,indomethacin and the mice gastric ulcers induced by histamine. ZHWK;10～15mg. kg-1ig decreased the amount of gastric juice, gastric acid and the activity of pepsin. ZHWK 5～20mg. kg- 1 ig increased the releasc of gastrie barrier mucus through Alcian-blue exper iment. ZHWK 10～20mg· kg-1 po accelerated the healing of gastric ulcer induced by acetic acid. The effect is relative with the dosage. ZHWK strongly inhibit the development of Helicobacter pylori (HP). The MIC is 0.024～0．048mg· ml-1.