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钯催化一锅法合成2炔基苯并呋喃的研究

Study on One-Pot Synthesis of 2-Ynyl-Benzofuran with Palladium as Catalyst
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摘要 在三乙胺与四氢呋喃混合溶剂中,邻乙炔基苯酚与E-1,2-二碘烯烃在醋酸钯及碘化亚铜的作用下,首先在室温下反应15h,然后在100℃左右继续反应,采用一锅法合成了4种2-炔基苯并呋喃化合物,该方法条件温和且产率较好,产物结构经由NMR和MS确证. Four 2-ynyl-benzofurans were synthesized by the reaction of 2-ethynylaniline and E-1,2-diiodoalkenes in the presence of palladium （II） acetate and copper （I） iodide as the catalysts via a one-pot reaction in a triethylamine-tetrahydrofuran medium. The reaction at room temperature for 15 h and then at 100 ℃ for the remaining time gave the desired 2-ynyl-benzofurans in moderate yields under mild conditions. The structures of the product were characterized and confirmed by MS and NMR spectrum.
作者 陶李明 刘文奇 周芸 周菊峰
机构地区 湘南学院化学与生命科学系
出处 《西南大学学报（自然科学版）》 CAS CSCD 北大核心 2010年第9期50-53,共4页 Journal of Southwest University(Natural Science Edition)
基金 湖南省自然科学基金资助项目(08JJ3018) 湖南省教育厅资助项目(08C828)
关键词 一锅法 合成 2-炔基苯并呋喃 one-pot synthesis 2-ynyl-benzofuran
分类号 O621.3 [理学—有机化学]
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参考文献11

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西南大学学报（自然科学版）
2010年 第9期

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