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缺铁孕妇胎盘铁相关蛋白受体同步检测及意义 被引量:1

DETECTION OF IRON-RELATED POTEIN RECEPTOR ON HUMAN PLACENTAL MICROVILLOUS MEMBRANE
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摘要 探讨胎盘微绒毛膜铁相关蛋白受体包括铁蛋白受体(FnR)、转铁蛋白受体(TfR)在孕母缺铁时表达的变化及其在母婴铁代谢中的作用,对此研究的重点是观察检测胎盘的有关指标。足月健康孕妇胎盘11例,轻度IDA孕妇胎盘14例。采用差速离心法提取胎盘微绒毛膜蛋白,采用受体放射配体结合分析法检查FnR、TfR。结果数据:11例健康孕妇胎盘TfR位点数为(4.057±1.32)×10sites/mg·pro,Ka值为(1.622±0.584)×10mol-1。L;FnR位点数为(3.534±1.105)×10sites/mg·pro,Ka值为(2.203±0.622)×10mol-1.L。14例轻度IDA孕妇胎盘TfR位点数为)6.984±1.754)×10sites/mg·pro,Ka为(1.541±0.794)×10mol·L;FnR位点数为(8.936±2.407)×10sites/mg.pro,Ka值为(1.249±0.365)×10mold-1f.L。轻度IDA孕妇胎盘TfR表达较正常高1.72倍,FnR表达较正常高出2.53倍。结果表明:轻度IDA孕妇胎盘TfR、FnR同步升高;此时胎盘可通过TfR、FnR的增?
出处 《中国小儿血液》 CAS 1999年第3期104-105,共2页 China Child Blood
基金 国家自然科学基金
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  • 1李强,中华血液学杂志,1992年,13卷,314页
  • 2廖清奎,中华医学杂志,1992年,72卷,619页
  • 3张之南,血液病诊断及疗效标准,1991年

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  • 1Grosbois B, Decaux O, Cador B, et al. Human iron deficiency. Bull Acad Natl Med, 2005,189:1649-1663.
  • 2Eisenstein RS. Iron regulatory proteins and the molecular control of mammalian iron metabolism. Annu Rev Nutr,2000,20:627 -662.
  • 3Georgieff MK, Berry SA, Wobken JD, et al. Increased placental iron regulatory protein-1 expression in diabetic pregnancies complicated by fetal iron deficiency. Placenta, 1999,20:87-93.
  • 4Hentze MW, Muckenthaler MU, Andrews NC. Balancing acts: molecular control of mammalian iron metabolism. Cell, 2004,117 : 285-297.
  • 5Gambling L, Danzeisen R, Gair S,et al. Effect of iron deficiency on placental transfer of iron and expression of iron transport proteins in vivo and in vitro. Biochem J, 2001,356:883-889.
  • 6Bradley J, Leibold EA, Harris ZL,et al. Influence of gestational age and fetal iron status on IRP activity and iron transporter protein expression in third-trimester human placenta. Am J Physiol Regul Integr Comp Physiol, 2004,287 : R894-901.
  • 7O Brien KO, Zavaleta N, Abrams SA,et al. Maternal iron status influences iron transfer to the fetus during the third trimester of pregnancy. Am J Clin Nutr, 2003,77:924-930.
  • 8Gambling L, Andersen HS, Czopek A,et al. Effect of timing of iron supplementation on maternal and neonatal growth and iron status of iron-deficient pregnant rats. J Physiol, 2004 ,561:195-203.
  • 9Perez EM, Hendricks MK, Beard JL, et al. Mother-infant interactions and infant development are altered by maternal iron deficiency anemia. J Nutr,2005 ,135 :850-855.
  • 10陈波斌,林果为,倪赞明,周嘉陵.血清转铁蛋白受体和血清铁蛋白在鉴别慢性病贫血和缺铁性贫血价值的评价[J].中华血液学杂志,2000,21(1):44-45. 被引量:55

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