左旋氧氟沙星血药浓度测定及药物动力学

Determination of levofloxacin in plasma and its pharmacokinetics

目的:测定国产左旋氯氟沙星胶囊po后在人体内的药物动力学.方法:10例健康志愿受试者,单次po国产左旋氯氟沙星胶囊,用反相高效液相色谱法测定血浆中药物浓度.结果:左旋氧氟沙星药物动力学参数分别为:C_(?)=(2.12±0.21)μg/ml,t_(?)=(1.16±0 18)h,T_(1/2α)=(1.50±0.65)H,T_(1/2β)=(6.16±1.15)h,CL=(16.27±2.15)L/h,V_d=(70.33±10.94)L,AUC_(0→∞)=(13.72±1.03)(Mg/L)·h.结论:国产左旋氧氟沙星胶囊的主要药物动力学参数与国外文献报道基本一致.

AIM: To study the pharmacokinetics of levofloxacin (LVFX). METHODS: A single oral dose of LVFX capsule was given to 10 Chinese male volunteers. Plasma levels were determined by reversed phase high-performance liquid chromatography (RP-HPLC). RESULTS:The in vivo dispostion of LVFX was belonged to a two-compartment model. The pharmacokinetic parameters were c_(max) = (2. 12 ± 0. 21 ) μg/ml, t_(max) = ( 1. 16 ± 0. 18 ) h, T_(1/2a)= (1. 50 ± 0. 65)h ,T_(1/2β)= (6. 16 ± 1. 15)h,CL= (16. 27 ± 2. 15)L/h,V_(d)= (70. 33 ± 10. 94) L,AUC_(0→∞) = (13. 72 ± 1.03) [(mg/L) · h] respectively. CONCLUSION : The pharma-cokinetic parameters are similar to those reported in foreign journals.