舌鳞癌患者舌苔形成与CD29和E-cad表达的相关性研究

Relationship Between Formation of Tongue Fur and Expressions of CD29 and E-cad in Patients with Tongue Squamous Cell Carcinoma

目的:探讨舌鳞癌患者舌苔形成与CD29和E-cad表达的关系。方法:选择口腔舌鳞癌切除术患者,根据不同舌苔分为白薄苔组、白厚苔组、黄薄苔组、黄厚苔组及剥苔组;并将胎儿正常白薄苔设为对照组。采用免疫组化S-P法检测不同舌苔黏膜组织中CD29和E-cad表达的情况。结果:CD29在白厚苔中表达最高,在黄薄苔中表达最低。E-cad在白薄苔中表达最高,在剥苔中表达最低。按舌苔厚薄来比较,CD29在厚苔中的高表达;而E-cad在薄苔中高表达。按苔色来比较,两者在白苔中的表达均高于黄苔。结论:舌鳞癌患者舌苔形成与CD29和E-cad表达水平的变化密切相关。

Objective：To investigate the relationship between the formation of tongue fur and expressions of CD29 and E-cadherin （E-cad） in patients with tongue squamous cell carcinoma. Methods： The patients with tongue squamous cell carcinoma were divided into five groups： white thin fur group,white thick fur group,yellow thin fur group,yellow thick fur group and non-fur group,with fetal white thin fur group as control. The expressions of CD29 and E-cad in tongue epithelial tissue were detected by immunohistochemistry S-P method. Results： The expression of CD29 was the highest in white thick fur group and was the lowest in yellow thin fur group. The expression of E-cad was the highest in white thin fur group and was the lowest in non-fur group. The expression of CD29 was higher in thick fur groups than that in thin fur groups and the expression of E-cad was higher in thin fur groups than that in thick groups. The expressions of CD29 and E-cad were higher in white fur groups than that in yellow fur groups. Conclusion： The formation of tongue fur is closely related to the expressions of CD29 and E-cad in patients with tongue squamous cell carcinoma.