男性健康人群和尖锐湿疣患者阴毛毛囊中人乳头瘤病毒的调查分析

Prevalence of human papillomavirus in the pubic hair follicles of healthy men and male patients with genital warts

目的：人乳头瘤病毒（human papillomavirus,HPV）在健康人群中广泛存在,但其在阴毛毛囊中的感染率目前尚不清楚,阴毛毛囊感染与尖锐湿疣的复发关系更不清楚,本课题旨在研究HPV在健康男性和尖锐湿疣患者阴毛毛囊中的感染情况,了解毛囊感染与尖锐湿疣复发的关系。方法：尖锐湿疣患者86例,年龄24~61岁,健康男性122例,年龄22~80岁,采用PCR技术对耻骨部阴毛毛囊中的HPV进行检测,并对两组资料进行分析。结果：男性尖锐湿疣患者的阴毛毛囊中HPV阳性率为32.55%（28/86）,其中17例为HPV6（19.77%）,7例为HPV11（8.14%）,2例为其他亚型,混合感染2例（同时检测到HPV6和HPV11,以下同）。健康人群阴毛毛囊中的HPV检出率为17.21%（21/122）,其中15例HPV6（12.30%）,4例为HPV11（3.28%）,1例其他亚型,1例为混合感染。结论：尖锐湿疣患者的阴毛毛囊中HPV感染率高于健康男性人群。尖锐湿疣患者与健康人群感染HPV的亚型基本相似,主要为HPV6和HPV11。

Objective：Human papillomavirus（HPV） commonly exists in healthy individuals,but its prevalence in the pubic hair follicles is not yet clear,nor is the relationship between HPV infection in the pubic hair follicles and the recurrence of genital warts in men.This study aimed to investigate HPV infection in the pubic hair follicles of healthy men and patients with genital warts,and to look into the correlation of HPV infection with recurrent genital warts.Methods：We included in this study 122 healthy men aged 21-80 years and 86 male patients with genital warts aged 24-61 years,detected HPV in their pubic hair follicles by PCR,and made comparative analysis of the data obtained from the two groups.Results：The positive rate of HPV in the pubic hair follicles of the healthy males was 17.21%（21/122）,including 15 cases of HPV6,4 HPV11,1 non-HPV6/11 and 1 the mixed type（both HPV6 and HPV11）,while that of the genital wart patients was 32.55%（28/86）,including 17 cases of HPV6,7 HPV11,2 non-HPV6/11 and 2 the mixed type.Conclusion：The incidence of HPV infection is higher in patients with genital warts than in healthy men,while the types of HPV involved are basically the same in the two groups,mainly HPV6 and HPV11.