使用放大系统对睾丸精子行形态选择性卵细胞胞质内单精子注射的临床结局分析

Intracytoplasmic morphologically selected sperm injection of testicular sperm:Clinical outcome in azoospermia patients

目的:探讨使用放大系统对睾丸精子行形态选择性卵细胞胞质内单精子注射术(ICSI)的临床结局。方法:回顾分析本中心2008年1月至2008年10月共66例无精子症患者行常规ICSI,2008年11月至2009年7月共39例无精子症患者用放大系统将睾丸精子放大6 000倍后,行卵细胞胞质内形态选择性单精子注射(IMSI)。结果:行ICSI的患者临床妊娠率为51.52%,种植率为30.67%,早期流产率为11.76%;行IMSI的患者临床妊娠率为56.41%,种植率为35.29%,早期流产率为4.50%。结论:无精子症患者的睾丸精子通过放大系统选择后行ICSI,早期流产率较常规ICSI有下降的趋势。

Objective：To assess whether intracytoplasmic morphologically selected sperm injection（IMSI） of testicular sperm improves the clinical outcome in patients with azoospermia.Methods：We performed conventional intracytoplasmic sperm injection（ICSI） for 66 patients diagnosed with azoospermia and IMSI for another 39 using testicular sperm selected at high magnification（×6 000）,and comparatively analyzed the clinical outcomes of the two techniques.Results：There were no statistically significant differences between conventional ICSI and IMSI in the rates of pregnancy（51.52% vs 56.41%） and implantation（30.67% vs 35.29%）,although the rate of early abortion was lower in the IMSI than in the ICSI group（4.50% vs 11.76%）.Conclusion：IMSI of testicular sperm may effect a lower rate of early abortion than conventional ICSI in patients with azoospermia.