伐地那非对肾阳虚、肾阴虚及肝气郁结型勃起功能障碍的疗效分析

Clinical efficacy of vardenafil on ED patients with kidney-yang or-yin deficiency or liver-qi stasis

目的:观察伐地那非对肾阳虚、肾阴虚及肝气郁结型勃起功能障碍(ED)的临床疗效。方法:将124例ED患者按中医辨证分为肾阳虚型ED(44例)、肾阴虚型ED(41例)、肝气郁结型ED(39例),所有患者每天服用伐地那非5 mg,总疗程为8周。结果:伐地那非能显著提高各型ED患者的勃起功能问卷-5(IIEF-5)和勃起质量表(EQS)评分,且各组间比较差别有统计学意义(P<0.01);伐地那非显著提高肾阳虚和肾阴虚型ED患者性交成功百分率(P<0.01),肝气郁结型ED在治疗后性交成功百分率也有明显提高(P<0.05);伐地那非还能显著提高各型ED患者阴茎勃起硬度,3组治疗后总体有效率分别为81.82%、73.17%、43.59%。结论:伐地那非对肾阳虚和肾阴虚型ED患者疗效优于肝气郁结型ED患者。

Objective：To study the clinical efficacy of vardenafil on erectile dysfunction（ED） patients with kidney-yang deficiency,kidney-yin deficiency or liver-qi stasis.Methods：Based on the syndromes of Traditional Chinese Medicine,124 ED patients were divided into Groups A（kidney-yang deficiency,n=44）,B（kidney-yin deficiency,n=41） and C（liver-qi stasis,n=39）.All the patients were treated with vardenafil at 5 mg daily for 8 weeks,and the therapeutic effects were evaluated by comparing the scores on IIEF-5 and Erection Quality Scale（EQS） before and after the treatment.Results：After vardenafil treatment,the IIEF-5 and EQS scores of the ED patients were markedly increased,with statistically significant differences among the three groups（P〈0.01）.The success rate of sexual intercourse was significantly improved in Groups A,B（P〈0.01） and C（P〈0.05）.And the hardness of penile erection was enhanced by 81.82%,73.17% and 43.59% respectively in the three groups of patients.Conclusion：Vardenafil is more effective for ED patients with kidney-yang or kidney-yin deficiency than for those with liver-qi stasis.Natl J Androl,2010,16（9）：856-859