儿童变态反应性疾病过敏原3504例调查分析

Investigation of allergens in 3 504 children with allergic diseases

目的了解儿童变态反应性疾病的过敏原状况,以便于有针对性的预防和治疗。方法对3504例各种变态反应性疾病患儿,采用UniCAP100系统检测血清fx5E(食物筛查试验)或Phadiatop(环境吸入性筛查试验),及血清特异性IgE。结果过敏性鼻炎、过敏性结膜炎、哮喘及丘疹性荨麻疹患儿的血清环境吸入性变应原阳性率明显高于食物性变应原,而过敏性紫癜及消化道疾病患儿的食物性变应原阳性率明显高于环境吸入性变应原。环境吸入性特异性IgE水平较高,屋尘、户尘螨、粉尘螨大部分达到6级,食物性特异性IgE水平较低,均在3级以下。结论不同的儿童变态反应疾病的食物和环境吸入过敏原有显著差异,环境吸入性特异性IgE水平较食物性特异性IgE高。

Objective To investigate the allergens of various allergic diseases in children.Methods Serum levels of Fx5E,Phadiatop and specific IgE were measured by the UniCAP100 System in 3 504 children with allergic diseases.Results The positive rate of aeroallergens was obviously higher than that of food allergens in children with allergic rhinitis,allergic conjunctivitis,asthma and papular urticaria.In contrast,the positive rate of food allergens was obviously higher than that of aeroallergens in children with Henoch-Schonlein purpura and digestive diseases.The serum specific IgE level of aeroallergens was higher than that of food allergens.The dust and mite specific IgE levels reached to grade 6,while the food allergen specific IgE levels were lower than grade 3.Conclusions Aaeroallergens or food allergens vary remarkably in different allergic diseases in children.The level of specific IgE of aeroallergens is higher than that of food allergens.