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SORL1基因多态性与散发性阿尔茨海默病关联分析 被引量：2

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摘要 目的分析SORL1基因多态性与散发性阿尔茨海默病(SAD)是否存在关联。方法采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术,检测114例SAD患者及111例健康对照者的SORL1基因多态性分布特征。结果 SAD组与对照组SORL1基因型及等位基因频率分布差异无统计学意义(χ2=1.693,P=0.429,χ2=0.965,P=0.326)。不同性别的SAD组与对照组SORL1基因型及等位基因频率分布差异无统计学意义(男性:χ2=2.324,P=0.313,χ2=1.667,P=0.197;女性:χ2=2.878,P=0.237,χ2=0.058,P=0.810)。结论亚洲汉族人群SORL1基因rs641120位点的A/GSNP多态性与SAD可能无关联。
作者 伍力 王燕 李超 伍星 余发春
机构地区 云南省精神病医院
出处 《中国老年学杂志》 CAS CSCD 北大核心 2010年第19期2754-2756,共3页 Chinese Journal of Gerontology
关键词 阿尔茨海默病 基因表达 多态现象 遗传
分类号 R749 [医药卫生—神经病学与精神病学]
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参考文献11

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同被引文献21

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中国老年学杂志
2010年 第19期

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