B7-H4与肾癌的研究进展

B7-H4 and renal cell carcinoma

肾癌又称肾细胞癌,起源于肾小管上皮细胞,占成人癌的3%,是泌尿系统发病率仅次于膀胱癌的第二常见的恶性肿瘤。早期肾癌无明显症状,需依靠影像学检查来与肾良性病变相鉴别。B7-H4是新近发现的B7-CD28家族成员,在T细胞免疫应答中起到负调节作用,研究表明其与肾癌的发生、发展及预后均有着联系,通过对B7-H4的研究将有助于对肾癌的早期诊断及免疫治疗提供新的方法。文中就国内外关于B7-H4与肾癌的有关研究进展进行综述。

Kidney cancer,also known as renal cell carcinoma,originates from renal tubular epithelial cells.It ranks second only to bladder cancer as the most common malignant tumor of the urinary system,accounting for 3% of adult malignancies.Early renal cell carcinoma presents no obvious symptoms,and therefore has to be differentiated from benign kidney diseases by imaging studies.B7-H4 is a newly discovered member of the B7-CD28 family,which plays a negative regulatory role in T-cell immune responses and has been shown to be associated with the development,progression and prognosis of renal cell carcinoma.Studies on B7-H4 may help provide new approaches to the early diagnosis and immunotherapy of renal cell carcinoma.