围产期缺氧对新生儿肺动脉压的影响

EFFECT OF PERINATAL HYPOXIA ON PULMONARY ARTERIAL PRESSURE IN NEONATES

目的 了解围产期缺氧对新生儿肺动脉压的影响及其与临床的关系。方法 对有围产期缺氧史的新生儿行超声心动图检查 ,测定肺血流参数 :RPEP、RVET、AT,计算 RPEP/RVET,RPEP/AT及 PAMP,比较不同程度缺氧时肺动脉压的变化 ,肺动脉压升高与临床的关系。结果 重度缺氧组 RPEP/RVET、RPEP/AT、PAMP明显高于轻度缺氧组 ,而 AT明显低于轻度缺氧组 ;临床有明显呼吸困难 ,酸中毒 ,吸氧所需时间 >3天者其肺动脉压升高的发生明显高于无上述表现者。结论 围产期缺氧可引起肺动脉压升高 ,而且缺氧越重 ,升高越明显 ;临床有不能用原发病解释的缺氧或酸中毒较重时 ,应注重肺动脉压力的变化 。

To in investigate the effect of perinatal hypoxia on pulmonary arterial pressure in neonates and it's relation to clinical manifestation. Methods Using echocardiography, RPEP,RVET and AT were measured in 52 neonates with perinatal hypoxia, RPEP/RVET, RPEP/AT,PAMP were calculated and compared the changes of pulmonary artery pressure in two groups with different hypoxic history degree, We studied the relation between the increment of pulmonary artery pressure and clinical manifestation. Results RPEP/RVET,RPEP/AT,PAMP were significantly higher and AT was lower in group of serious hypoxia than in group of mild hypoxia, pulmonary artery pressure was significantly higher in cases with serious dyspnea, acidosis and those who needed oxygen supplied more than three days than those who had no such clinical manifestations, Conclusion Perinatal hypoxia can lead to the increment of pulmonary artery pressure, we should pay attention to the change of pulmonary artery pressure and administrate suitable tretment early.