摘要
目的：探讨巴曲酶对单侧颞叶缺血性损害大鼠空间认知加工能力的改善作用及与ＰＤＧＦ表达的关系。方法：用Ｍｏｒｉｓ迷宫监测大鼠空间认知能力，行为。实验结束后取脑进行梗死体积测定及ＰＤＧＦ免疫组化分析。结果：（１）、巴曲酶可以显著地缩短梗死大鼠在Ｍｏｒｉｓ迷宫中搜索目标的平均反应时和行程；（２）、巴曲酶组大鼠较多、较早地使用了正常的认知策略。巴曲酶治疗组颞叶梗死体积较单纯梗死组显著缩小，ＰＤＧＦＡ表达明显减少。结论：提示巴曲酶对单侧颞叶梗死大鼠空间认知功能障碍确有改善作用，其物质基础是巴曲酶减小了梗死体积，ＰＤＧＦＡ表达与颞叶损害有关联。
Objective: The effects of Batroxobin on spatial
cognition with left temporal infarction of rats and the expression of PDGFA were investigated.
Methods: The spatial cognition ability of rats were monitered by Morris water maze.Then the
rats brains were analysed by HE and PDGF immunohistochemistry. Results: Batroxobin
reduced the reaction time and distance of this kind of spatial learning test Moreover,the rats of
Batroxobin groups used normal strategies more often,and the strategiese changed more fast
than that of the damage group.Batroxobin reduced the size of the infarction and downregulated
the expression of PDGFA. Conclusion: Batroxobin can improve spatial learning ability of the
temporal infarct rats,which at least based on reducing the infarction.The downregulation of the
expression of PDGFA probably is related to the neuroprotective mechanism.
出处
《卒中与神经疾病》
1999年第2期74-76,共3页
Stroke and Nervous Diseases
