多发性硬化患者血清中可溶性白细胞介素-2受体的研究

A study on the serum levels of soluble interleukin2 receptor in patients with multiple sclerosis

目的：探讨多发性硬化（ＭＳ）患者血清中可溶性白细胞介素２受体（ｓＩＬ２Ｒ）水平的变化及临床意义。方法：采用双抗体夹心ＥＬＩＳＡ法检测了２８例ＭＳ患者和３５例正常对照组血清ｓＩＬ２Ｒ水平。结果：；ＭＳ患者中，急性复发组和缓解组血清中ｓＩＬ２Ｒ水平均显著高于正常对照组（Ｐ＜０．０１），而急性复发组患者ｓＩＬ２Ｒ水平又较缓解组增高（Ｐ＜０．０５），且与病情严重程度有关。结论：ＭＳ患者血清ｓＩＬ２Ｒ水平异常增高，这一指标可用于评估机体免疫状态和作为ＭＳ患者病情严重程度的标志。

Objective: To explore the serum of levels of soluble interleukin2 receptor (slL2R) in Multiple Sclerosis (MS) and its clinical implications. Methods: The serum levels of slL2R were measured in 28 patients with MS and 35 healthy peasons by using sandwiched ELISA assay. Results: The slL2R levels in patients with MS,either the relaping or the remitting,were significantly higher than those in normal group (P<0.01).On the other hand,the slL2R levels in relaping MS group was higher than that in remitting MS (P<0.05),and the increase of them corresponded with the severity of affected patients. Conclusion: There was an abnormal increase of the serum levels of slL2R in patients with MS.Soluble lL2R levels may serve as a useful parameter reflecting immunity and represent a marker of disease severity in MS.