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多发性硬化患者血清中可溶性白细胞介素-2受体的研究

A study on the serum levels of soluble interleukin2 receptor in patients with multiple sclerosis
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摘要 目的:探讨多发性硬化(MS)患者血清中可溶性白细胞介素2受体(sIL2R)水平的变化及临床意义。方法:采用双抗体夹心ELISA法检测了28例MS患者和35例正常对照组血清sIL2R水平。结果:;MS患者中,急性复发组和缓解组血清中sIL2R水平均显著高于正常对照组(P<0.01),而急性复发组患者sIL2R水平又较缓解组增高(P<0.05),且与病情严重程度有关。结论:MS患者血清sIL2R水平异常增高,这一指标可用于评估机体免疫状态和作为MS患者病情严重程度的标志。 Objective: To explore the serum of levels of soluble interleukin2 receptor (slL2R) in Multiple Sclerosis (MS) and its clinical implications. Methods: The serum levels of slL2R were measured in 28 patients with MS and 35 healthy peasons by using sandwiched ELISA assay. Results: The slL2R levels in patients with MS,either the relaping or the remitting,were significantly higher than those in normal group (P<0.01).On the other hand,the slL2R levels in relaping MS group was higher than that in remitting MS (P<0.05),and the increase of them corresponded with the severity of affected patients. Conclusion: There was an abnormal increase of the serum levels of slL2R in patients with MS.Soluble lL2R levels may serve as a useful parameter reflecting immunity and represent a marker of disease severity in MS.
作者 叶心国
出处 《卒中与神经疾病》 1999年第2期90-91,共2页 Stroke and Nervous Diseases
关键词 多发性硬化 受体 白细胞介素-2 Multiple SclerosisReceptorSoluble interleukin2
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  • 1杨荫昌,北京医学,1987年,9卷,364页
  • 2杨荫昌

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