血管紧张素转换酶基因多态性与高血压并脑梗死的关系

Insertion/deletion polymorphism of ACE gene associated with essenteal hypertension complicated by ischemic stroke

目的：探讨中国人中血管紧张素转换酶（ＡＣＥ）基因插入／缺失（Ｉ／Ｄ）与脑梗死的关系。方法：原发性高血压患者８９例，其中并发脑梗死４１例，正常对照组３０例。应用ＰＣＲ技术检测ＡＣＥ基因１６内含子的Ｉ／Ｄ多态性片段可分为三种基因型：纯合子缺失型（ＤＤ），纯合子插入型（Ｉ），杂合子型（ＩＤ）。结果：显示，高血压并发脑梗死患者的Ｄ等位基因频率（０．６４）高于单纯ＥＨ（０．４２）和正常对照组（０．４５）。结论：认为ＡＣＥ基因缺失多态性与中国人高血压并发脑梗死有关。

Objective: TO analyse angiotensin onverting enzyme (ACE) gene polymorphism in essential hypertensive with ischemic stroke among Chinese population. Methods: A 287bp I/D polymorphism in intron 16 of the ACE gene was examined by ploymerase chain reaction in a study of 89 esseatial hypertension patients (41 cases complicated with ischemic stroke) and 30 age and sexmatched controls.ZResults: Polymorphism of the ACE gene was categorized into three genotypes:two deletion alleles (genotype II).The frequencies of D alleles in essential hypertension with ischemic stroke (0.54) were significantly higher than those in hypertensive (0.42) and control subjects (0.45). Conclution5BZ: The results suggest that the D alleles is associated with essential hypertension with ischemic stroke.