家兔血液流变学参数及其影响因素

Study on Hemorrheological Parameters and Its Effective Factors in Healthy Rabbits

目的检测正常家兔血液流变学指标，建立其正常参考值，并对有关影响因素进行探讨。方法采用ＮＸＥ－１型锥板式粘度计。测定５．７５５^(－１)～３０７．２Ｓ^(－１)七个切变率的血液表观粘度、血浆粘度、红细胞硬度指数（ＴＫ）、红细胞聚集指数（ＲＡＩ）和氧释放系数（ＯＤ）。结果雄性组家兔高切变率和低切变率下的血液粘度及ＲＡＩ较雌性组明显增高（Ｐ<０．０５和Ｐ<０．０１），而ＯＤ较雌性组明显降低（Ｐ< ０．０５）。高体重组家兔高、中、低各切变率下的血液粘度和红细胞压积（Ｈｃｔ）较低体重组明显增高（Ｐ< ０．０５和Ｐ<０．０１），而ＯＤ明显低于低体重组（Ｐ<０．０５）。高Ｈｃｔ组家兔的血液粘度、ＯＤ较低Ｈｃｔ组明显增高（Ｐ均<０．０１），而血浆粘度和ＴＫ较低Ｈｃｔ组明显降低（Ｐ＜０．０５和Ｐ<０．０１）。结论家兔不同性别、体重和Ｈｃｔ，其血液流变学指标存在明显差异。

Objective To establish the normal reference ranges of hemorrheological parameters and explore its effective factors in healthy rabbits. Methods Apparent viscosity of blood、plasma viscosity、red blood cell aggregation index(RAI)、red blood cell rigidness index (TK) and oxygen diffusion index (OD) were measured using NXE-1 type cone-plate viscometer. Results The low and high shear rate apparent viscosity of blood.RAI of male rabbits group were increased and OD were deceased compared with female rabbits group.The apparent viscosity of blood in low、middle and high shear rate and hematocrit were increased and OD were decreased in high body weight rabbits group compared with low body weight rabbits group. Apparent viscosity of blood and OD were increased and plasma viscosity and TK were decreased in high hematocrit rabbits group compared with low hematocrit rabbits group. Conclusions Hemorrheological parameters have obvious difference in rabbits of different sex、body weight and hematocrit.