摘要
目的探讨东菱克栓酶（ＤＦ－５２１）对大鼠肠系膜微动脉血栓的溶栓时间和机制。方法采用光化学诱导法和静脉注射荧光素钠制作大鼠肠系膜微动脉血栓模型，经显微电视摄像系统和多媒体计算机图像处理技术相结合，定量分析不同剂量组ＤＦ－５２１的溶栓时间以及血管再通程度。结果ＤＦ－５２１治疗后，８Ｕ／ｋｇ和１６Ｕ／ｋｇ组平均再通时间分别为２６．７±９．４ｍｉｎ和４５±４３．６ｍｉｎ；溶栓后血管再通管径与该部位血管初始直径之比大于２５％时，再通血管不会出现再闭塞现象。讨论东菱克栓酶对大鼠微动脉血栓具有可靠的治疗效果。
Objective To evaluate the duration and the mechanism of batroxobin (DF-521) in treating microarterythrombosis of rat mesentery.Methods Microarterythrombus formation model was made by the filtered light irradiation and intravascular fluorescein sodium administration,the duration and extent of recanalization in different dosagegroups were measured using computer image subtraction. Results The mean time of recanalization is 26.7?. 4min in 8U/kg group and 45?3.6min in 16U/kg group respectively,the reocclusion doesn't happen when the caliber of the recanalization is over 25% of the diameter of the microartery.Conclusion Batroxobin shows a good curative effect on microarterythrombus of rat mesentery.
出处
《中国微循环》
1999年第2期99-101,共3页
Journal of Chinese Microcirculation
