血清视黄醇结合蛋白检测在肝脏疾病诊断中的应用价值

Diagnostic value of serum retinol-binding protein in liver diseases

目的研究血清视黄醇结合蛋白(RBP)测定以及在肝脏疾病诊断中的应用价值。方法利用免疫比浊法检测64例不同类型肝病患者及40例正常人的血清RBP水平,同时检测血清白蛋白(ALB)浓度作对比,并对其中32例急性肝炎患者作动态观察。结果急性肝炎患者入院时血清RBP明显下降,而血清ALB下降不明显,治疗1月后血清RBP明显回升,而血清ALB明显下降;慢性肝炎患者血清RBP、ALB结果都偏低,与正常对照组比较差异无统计学意义;肝炎后肝硬化患者血清RBP、ALB下降明显。结论血清RBP可作为反映急性肝损害的敏感指标,对肝脏疾病的诊断和预后判断有重要的参考价值。

Objective To explore the value of the detection of serum RBP （retinol-binding protein） in the diagnosis of different liver disease. Methods The serum levels of RBP of 64 cases of different liver diseases and 40 cases of healthy adults were detected with the immunoturbidimetry method and the levels of serum ALB （albumin） of 32 cases of acute hepatitis were observed dynamically. Results In admission to hospital, the serum levels of RBP of acute hepatitis patients declined significantly and the serum levels of ALB declined inconspicuously. After the patients were cured for a month, the serum levels of RBP ascended distinctly, and at the same time the serum levels of ALB declined visibly. The serum levels of RBP and ALB were little lower in chronic hepatitis patients, and there were no differences between them and healthy adults. The serum levels of RBP and ALB of the hepatocirrhcosis patients due to hepatitis all declined. Conclusions The serum RBP is a sensitive index reflecting liver damnification and is better than serum ALB. It is valuable to measure the levels of RBP in diagnosis and prognosis judgment of liver diseases.