精浆酸性磷酸酶活性与抗精子抗体

A study on the relationship between ACP concentration in seminal plasma and semen parameters

目的：探讨男性不育症精浆酸性磷酸酶（ＡＣＰ）与精子密度、精子成活率、血清和精浆抗精子抗体（ＡｓＡｂ）之间的关系。方法：检测不育男性精子密度、精子活率、血清和精浆ＡｓＡｂ及精浆ＡＣＰ活性。结果：精子成活率＞５０％、３０％～５０％、＜３０％组的精浆ＡＣＰ活性逐渐降低，分别为（１６２．１２±８５．７７）Ｕ／ｍｌ、（１２３．０１±５２．５５）Ｕ／ｍｌ和（１１１．２１±５４．４２）Ｕ／ｍｌ；与成活率＞５０％的精浆ＡＣＰ相比，活率在３０％～５０％和＜３０％组的ＡＣＰ活性降低，具有显著性差异（ＳＮＫ检验，Ｐ＜０．０１）；精子密度＞２０×１０９／Ｌ、（１０～１９）×１０９／Ｌ和＜１０×１０９／Ｌ组的精浆ＡＣＰ活性依次下降，分别为（１６５．９９±８８．６７）Ｕ／ｍｌ、（１３９．１９±７０．７８）Ｕ／ｍｌ和（１１５．２１±６０．５１）Ｕ／ｍｌ；与密度＞２０×１０９／Ｌ组的ＡＣＰ活性相比，密度在（１０～１９）×１０９／Ｌ和＜１０×１０９／Ｌ的精浆ＡＣＰ活性降低，具有显著性差异（ＳＮＫ检验，Ｐ＜０．０１）；血清、精浆ＡｓＡｂ阳性病人的ＡＣＰ活性明显低于二者均阴性的病人，且ＡＣＰ降低具有显著性差异（ＳＮＫ检验，Ｐ＜０．０１）。结论：?

Objectives: To study the relationship among ACP concentration in seminal plasma and sperm density,sperm vitality,antisperm antibody in serum and seminal plasma in infertile men. Methods: Sperm density,sperm vitality,AsAb in serum and seminal plasma and ACP concentration in seminal plasma were measured in infertile men. Results: ACP concentration in seminal plasma decreased sequentially among sperm vitality>50%,30%￣50%,<30%, were(162. 1285.77) U/ml,(123.0152.55) U/ml and (111.2154.42) U/ml respectively,and there were statistional differences on ACP concentration between sperm vitality>50% and 30%￣50%,or <30%(P<0.01).ACP concentration in seminal plasma decreased sequentially among sperm density>20109/L,(10￣19)109/L and <10109/L,they were (165.9988.67) U/ml,(139.1970.78) U/ml and (115.2160.51) U/ml,and there were statistical differences on ACP concentration between sperm density >20109/L and (10￣19)109/L,or <10109/L(P<0.01).There were statistical differences between positive of AsAb in serum,and/or seminal plasma and negative of it (P<0.01),and ACP concentration in seminal plasma increased obviously. Conclusions: ACP is one of the components of immunosuppresive factors existing in human semen,which is very important in infertile men.