欧洲千里光化学成分的研究

Chemical constituents in Senecio vulgaris

目的研究欧洲千里光Senecio vulgaris的化学成分。方法采用硅胶柱色谱进行分离纯化,通过理化性质和波谱数据鉴定结构。结果从欧洲千里光甲醇提取物中分离鉴定了11个化合物,分别为环阿尔廷-23Z-烯-3β,25-二醇(cycloart-23Z-ene-3β,25-diol,1)、1β,6α-二羟基桉烷-4(15)-烯(1β,6α-dihydroxyeudesm-4(15)-ene,2)、黑麦草内酯(loliolide,3)、1β,5α-二当归酰氧基-桉烷-(15)-烯(1β,5α-diangeloyloxy-eudesm-(15)-ene,4)、1β,7α-二羟基桉烷-4(15)-烯(1β,7α-dihydroxyeudesm-4(15)-ene,5)、刺参酮(oplopanone,6)、1-羟基-4-氧代-2,5-环己二烯-1-醋酸甲酯(蓝花楹酮,jacaranone,7)、1′-羟基-2′-甲氧基-4′-环己烯-醋酸甲酯(1′-hydroxy-2′-methoxy-4′-oxocyclohexanac-etate methyl,8)、4-(醋酸甲酯)-4-羟基-环己酮(4-carbomethoxymethyl-4-hydroxycyclohexanone,9)、1-羟基-2,6-二甲氧基-4-环己烯-醋酸甲酯(1-hydroxy-2,6-di methoxy-4-oxocyclohexanacetate methyl,10)、2-[2,2-二甲基-6-氧-7-二氢-1,3-苯并二氧戊环-3(6-氢)-基]-醋酸甲酯(2-[2,2-di methyl-6-oxo-7-dihydro-1,3-benzodioxol-3(6 H)-yl]aceatemethyl,11)。结论 11个化合物均是首次从欧洲千里光中分离得到。

Objective To study the chemical constituents in Senecio vulgaris.Methods The column chromatography was used for the isolation of chemical constituents.Their structures were identified on the basis of spectroscopic evidence and physiochemical properties.Results Eleven compounds were isolated from S.uvlgaris and their structures were identified as： cycloart-23Z-ene-3β,25-diol（1）,1β,6α-dihydroxyeudesm-4（15）ene（2）,loliolide（3）,1β,5α-diangeloyloxy-eudesm-（15）-ene（4）,1β,7α-dihydroxyeudesm-4（15）-ene（5）,oplopanone（6）,jacaranone（7）,1′-hydroxy-2′-methoxy-4′-oxocyclohexanacetate methyl（8）,4-carbomethoxymethyl-4-hydroxycyclohexanone（9）,1-hydroxy-2,6-dimethoxy-4-oxocyclohexanacetate methyl（10）,and 2-[2,2-dimethyl-6-oxo-7-dihydro-1,3-benzodioxol-3（6H）-yl] aceate methyl（11）.Conclusion All compounds were obtained from this plant for the first time.