摘要
p53-MDM2蛋白相互作用是抗肿瘤药物研究的重要作用靶点,抑制p53-MDM2结合是激活p53的有效途径。大量的药物筛选方法和手段已经用于寻找p53-MDM2相互作用的新型抑制剂,其中小分子抑制剂是最具前景的研究领域之一。该文总结了近年来国内外p53-MDM2蛋白结合小分子抑制剂的研究进展。
p53-MDM2 protein-protein interaction is an important target for antitumor drugs.Inhibiting p53-MDM2 interaction is a promising approach for activating p53.A number of drug screening approaches and technologies have been used to identify novel inhibitor of p53-MDM2 interaction.And small-molecule inhibitors research is one of the most promising areas.The advances on small-molecule inhibitors of p53-MDM2 protein interactions at home and abroad in recent years were summarized.
出处
《中国药物化学杂志》
CAS
CSCD
2010年第5期403-407,413,共6页
Chinese Journal of Medicinal Chemistry
基金
上海市科技攻关重点项目(09431901700)
