小分子c-Met激酶抑制剂的研究进展

Progress on c-Met kinase inhibitors

c-Met激酶与肿瘤的发生、发展和转移密切相关。c-Met激酶小分子抑制剂的研究为多种类型肿瘤提供了一种新的靶向治疗手段。该文重点介绍近年来报道的不同结构类型的c-Met激酶小分子抑制剂,并对其活性和构效关系进行综述。

c-Met kinase contributes to tumorigenesis,tumor progression,and metastasis in numerous human malignancies.The development of small-molecule inhibitors of c-Met kinase has led to well-tolerated,targeted therapies for a growing number of cancer types.Recent developments in different chemical types of c-Met kinase inhibitors were highlighted in this view.The biological activity and the structure-activity relationship aspects were also described.