水飞蓟宾-磷脂复合物的药动学及临床研究现状

Current status of pharmacokinetics and clinical study of silybin-phospholipid complex

脂肪肝是由多种原因引起的肝脏脂肪代谢异常,水飞蓟宾-磷脂复合物(水飞蓟宾胶囊,商品名水林佳)属中药制剂,其主要成分是水飞蓟宾和磷脂酰胆碱,其中水飞蓟宾是从水飞蓟种子中提取的黄酮类化合物,具有抗氧自由基、抗脂质过氧化、保护和修复肝细胞膜等作用;水飞蓟宾与磷脂酰胆碱结合后,通过独有的卵磷脂固体分散技术生产,可提高药物吸收和生物利用度,使药效进一步提高。文中对水飞蓟宾-磷脂复合物用于脂肪肝和乙肝的临床疗效、联合用药及药动学特征等进行综述。

Despite of multiple causes,fatty liver,also known as fatty liver disease,can be considered as a single disease of fat metabolism defects.Silybin-phospholipid complex,as a Traditional Chinese Medicine,consists of silymarin and lecithin.Silymarin is a mixture of flavonolignans（mainly silybin） from the seeds of silybum marianum.Silymarin is one of the most effective liver-protecting substances.Its action is inhibition of free radical damage and the lipoxygenase enzyme.Lecithin is a biological emulsifier increasing the solubility of fat and cholesterol,and can increase drug absorption and bioavailability.In this paper,we reviewed the research status of silybin-phospholipid complex in its pharmacokinetics,drug combination,and clinical study in fatty liver disease and chronic viral hepatitis.