摘要
Conformations of surface atoms in various stages of nanogold-based genechip testing are scanned by the atomic force and scanning tunneling microscope. We intuitively observe the process and differences in probe combination, nucleic acid hybridization, and silver staining, which might be useful to validate the assay method of genechip. We hope to use this technology to make the other invisible chemical or biochemical reaction become visible and convincible in the future.
Conformations of surface atoms in various stages of nanogold-based genechip testing are scanned by the atomic force and scanning tunneling microscope. We intuitively observe the process and differences in probe combination, nucleic acid hybridization, and silver staining, which might be useful to validate the assay method of genechip. We hope to use this technology to make the other invisible chemical or biochemical reaction become visible and convincible in the future.
基金
supported by the National Natural Science Foundation of China (Nos. 30300326 and 30972827)
the Military Equipment Service Science Research and Innovation Project (No. 2-09011)
the Science and Technology Project of Shenzhen (Nos. JH200504270119Aand HZ0907004),the Science and Technology Project of Nanshan, Shenzhen (No. SN200603200)
the Science and Technology Project of General Administration of Quality Supervision, Inspection and Quarantine, P. R.China (No. 2008IK256-03)
