摘要
IL-5是一种T细胞产生的细胞因子，它可以激活可转化为终末细胞的B细胞成为免疫球蛋白产生细胞。IL-5除了由抗原刺激的Th2细胞产生外，也可以由过敏原或IgE复合物刺激的肥大细胞产生。IL-5与抗CD38结合作为B细胞增殖时的共刺激分子发挥促进B细胞分化作用。IL-5对嗜酸性粒细胞的影响主要表现在分化、迁移、活化和存活等4个方面。在过敏性疾病及寄生虫感染造成的病理损伤中，IL-5也发挥重要作用，因此，以IL-5为靶标的治疗手段也日益受到重视，并已获得初步成果。
IL-5 is a kind of cytokines produced by T cells, which can induce terminal differentiation of activated B cells into antibody-forming cells. IL-5 produced by Th2 cells and by mast cells upon stimulation with allergen/IgE complex. IL-5 acts as a co-activator for B cells proliferation when in combination with anti-CD38. The effects of IL-5 on eosinophils largely fall into 4 categories, differentiation, migration, activation and survival. IL-5 plays an important role in the pathological process of allergic disease and parasitic infection, so researchers paid growing attention to IL-5 as the targets of the treatment methods and got some results.
出处
《国际医学寄生虫病杂志》
CAS
2010年第5期278-283,共6页
International JOurnal of Medical Parasitic Diseases
基金
“973项目”（2010CB530004-）
